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  <link:roleRef roleURI="http://mimedx.com/role/QuarterlyFinancialData" xlink:type="simple" xlink:href="mdxg-20201231.xsd#QuarterlyFinancialData"/>
  <link:calculationLink xlink:role="http://mimedx.com/role/QuarterlyFinancialData" xlink:type="extended"/>
  <link:roleRef roleURI="http://mimedx.com/role/QuarterlyFinancialDataTables" xlink:type="simple" xlink:href="mdxg-20201231.xsd#QuarterlyFinancialDataTables"/>
  <link:calculationLink xlink:role="http://mimedx.com/role/QuarterlyFinancialDataTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://mimedx.com/role/QuarterlyFinancialDataDetails" xlink:type="simple" xlink:href="mdxg-20201231.xsd#QuarterlyFinancialDataDetails"/>
  <link:calculationLink xlink:role="http://mimedx.com/role/QuarterlyFinancialDataDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://mimedx.com/role/SubsequentEvents" xlink:type="simple" xlink:href="mdxg-20201231.xsd#SubsequentEvents"/>
  <link:calculationLink xlink:role="http://mimedx.com/role/SubsequentEvents" xlink:type="extended"/>
  <link:roleRef roleURI="http://mimedx.com/role/ScheduleIIValuationandQualifyingAccounts" xlink:type="simple" xlink:href="mdxg-20201231.xsd#ScheduleIIValuationandQualifyingAccounts"/>
  <link:calculationLink xlink:role="http://mimedx.com/role/ScheduleIIValuationandQualifyingAccounts" xlink:type="extended"/>
  <link:roleRef roleURI="http://mimedx.com/role/ScheduleIIValuationandQualifyingAccountsDetails" xlink:type="simple" xlink:href="mdxg-20201231.xsd#ScheduleIIValuationandQualifyingAccountsDetails"/>
  <link:calculationLink xlink:role="http://mimedx.com/role/ScheduleIIValuationandQualifyingAccountsDetails" xlink:type="extended"/>
</link:linkbase>
