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  <xs:element id="mdxg_NumberofBoardMemberswithModifiedOptionGrants" abstract="false" name="NumberofBoardMemberswithModifiedOptionGrants" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="mdxg_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsGrantsFairValue" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsGrantsFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="mdxg_LegalSettlementAmountPaidByThirdParty" abstract="false" name="LegalSettlementAmountPaidByThirdParty" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="mdxg_TemporaryEquityConversionThresholdTradingDays" abstract="false" name="TemporaryEquityConversionThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="mdxg_ContingencyLossNumberofFormerEmployees" abstract="false" name="ContingencyLossNumberofFormerEmployees" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="mdxg_AccruedClinicalTrialsCurrent" abstract="false" name="AccruedClinicalTrialsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mdxg_TemporaryEquityThresholdConsecutiveTradingDays" abstract="false" name="TemporaryEquityThresholdConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="mdxg_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodModificationOfPriorYearWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodModificationOfPriorYearWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:perShareItemType"/>
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  <xs:element id="mdxg_NumberofDepositoryInstitutions" abstract="false" name="NumberofDepositoryInstitutions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="mdxg_DeferredTaxAssetLeaseObligation" abstract="false" name="DeferredTaxAssetLeaseObligation" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="mdxg_DebtInstrumentDefaultInterestRate" abstract="false" name="DebtInstrumentDefaultInterestRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="mdxg_TemporaryEquityAccretionofIncreasingrateDividendFeature" abstract="false" name="TemporaryEquityAccretionofIncreasingrateDividendFeature" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="mdxg_ContractWithCustomerAssetDecreaseForCashCollected" abstract="false" name="ContractWithCustomerAssetDecreaseForCashCollected" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mdxg_RestrictedStockAndRestrictedStockUnitAwardsMember" abstract="true" name="RestrictedStockAndRestrictedStockUnitAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="mdxg_HayfinLoanAgreementTermLoanMember" abstract="true" name="HayfinLoanAgreementTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="mdxg_BTLoanAgreementMember" abstract="true" name="BTLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="mdxg_TemporaryEquityIncreasingrateDividendFeature" abstract="false" name="TemporaryEquityIncreasingrateDividendFeature" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="mdxg_MinimumAgeForAdditionalContributionBeyondNormalPlan" abstract="false" name="MinimumAgeForAdditionalContributionBeyondNormalPlan" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
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  <xs:element id="mdxg_CustomerAndSupplierRelationshipsMember" abstract="true" name="CustomerAndSupplierRelationshipsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
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  <xs:element id="mdxg_ContractWithCustomerAssetRollForward" abstract="true" name="ContractWithCustomerAssetRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="mdxg_NumberofBoardSeatsElectedbyTemporaryEquityHolders" abstract="false" name="NumberofBoardSeatsElectedbyTemporaryEquityHolders" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="mdxg_RelatedPartyTotalCompensationMember" abstract="true" name="RelatedPartyTotalCompensationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="mdxg_WriteOffofUnamortizedDeferredFinancingCosts" abstract="false" name="WriteOffofUnamortizedDeferredFinancingCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
